Name |
Year Published/ Journal |
Indication |
Total N° Patients |
Argami |
1996 |
Acute Myocardial Infarction |
120 |
ASSENT I |
1999(American Heart Journal) |
Myocardial Infarction |
3 325 |
ASSENT II |
1999 (The Lancet) |
Myocardial Infarction |
16 949 |
ASSENT III |
2001 (The Lancet) |
Myocardial Infarction |
6 000 |
ASSENT III + |
2003 (Circulation ) |
Myocardial Infarction |
1639 |
ATPAL / DIPACTI |
1993 |
Myocardial Infarction |
500 |
Caprie |
1996 (The Lancet) |
Myocardial Infarction, Ischemic Cerebrovascular Accident, Peripheral Arterial Disease |
19 185 |
Captors II |
2003 (American Heart Journal) |
Myocardial Infarction |
max 400 |
COBALT |
1997( N Eng J Med)
1999(Herz) |
Myocardial Infarction |
7 169 |
Entire |
- |
Myocardial Infarction with ST Elevation |
320 |
Faster |
- |
Myocardial Infarction with ST Elevation |
800 |
GISSI-2/INT. TPA-SK TRIAL |
1990(The Lancet)
1992( N Engl. J. Med)
1992(European Heart Journal)
1996(J. Hypertens) |
Myocardial Infarction |
20 891
(extended study: 12 490 from Gissi-2; 8 401 non-Italian patients) |
GUSTO I |
1993( N Engl Med J)
1996(Circulation)
1996(J Am Coll Cardiol) |
Myocardial Infarction |
41 021 |
Gusto IIb |
1994(Circulation)
1996 ( N Engl Med J) |
Myocardial Infarction, Unstable Angina |
12 142 |
GUSTO-IIa |
1994(Circulation)
1996( N Engl Med J) |
Myocardial Infarcion, Unstable Angina |
2 564 |
GUSTO-III |
1997( N Eng J Med) |
Myocardial Infarction |
15 000 |
HERO-2 |
2002 (The Lancet) |
Myocardial Infarction |
17 000 |
Integrity |
- |
Myocardial Infarction |
396 |
Ibopamine |
1994 |
Congestive heart failure, NYHA Class II & III |
224 |
Late |
1993 (The Lancet)
1995 (J Am Coll Cardiol) |
Myocardial Infarction |
5 711 |
MK 383 |
1996 |
Unstable Angina, Non-Q-wave Myocardial Infarction |
3 100 |
Otelloh |
1999 |
Hypertension |
660 |
Paradigm |
1998 (J Am Coll Cardiol) |
Myocardial Infarction |
353 |
PARAGON-A |
1997 (J Am Coll Cardiol) |
Non Q-wave Myocardial Infarction, Unstable Angina |
2282 |
PARAGON-B |
2000 (Am Heart J) |
Unstable Angina, Non Q-wave Myocardial Infarction |
5225 |
PENTALYSE |
2000 |
Myocardial Infarction |
332 |
RAPT |
1994 (Circulation) |
Myocardial Infarction |
907 |
Realize |
1991 |
Myocardial Infarction |
300 |
Rocket |
1991 (European Heart Journal) |
Acute Coronary Syndromes |
52 |
Shock |
2000 (J Am Coll Cardiol) |
Myocardial Infarction |
302 |
SYMPHONY |
1999 (American Heart Journal) 2000 (The Lancet) |
Post-Myocardial Infarction, Post-Unstable Angina |
9233 |
SYMPHONY-2 |
1999 |
Non Q Wave Myocardial Infarction, Unstable Angina |
2576 |
TIMI 10B |
1999 (Circulation) |
Myocardial Infarction |
837 |
TIMI-14A |
1999 (Circulation) |
Myocardial Infarction |
888 |
TIMI-15B |
2000 |
Myocardial Infarction |
- |
Valiant |
2003 (New England Journal of medicine ) |
Myocardial Infarction |
14 500 |
ASSENT3 PLUS |
2003 (Circulation) |
Myocardial Infarction |
1639 |
REPLACE |
2003 (JAMA) |
PCI |
6010 |
ASSENT4 PCI |
2006 (Lancet) |
Myocardial Infarction |
1667 |
MERLIN-TIMI36 |
2007 (JAMA) |
Non ST ACS |
6560 |
ECASS III |
2008 (NEJM) |
Stroke |
821 |
TROICA |
2008 (NEJM) |
Cardiac Arrest |
1050 |
TRITON-TIMI38 |
2009 (Lancet) |
Myocardial Infarction |
3534 |
TRA-2P TIMI50 |
ongoing |
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SALVAGE |
ongoing |
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STROMBOLI |
ongoing |
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