LRND

Newsflash

Publications

 

Selected significant publications

 

  • De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F. Deficiency of presenilin 1 inhibits the normal cleavage of Amyloid Precursor Protein. Nature 1998; 391:387-390, accompanied by News and Views. (Full pdf)

  • Serneels L, Dejaegere T, Craessaerts K, Horré K, Jorissen E, Tousseyn T, Hébert S, Coolen M, Martens G, Zwijsen A, Annaert W, Hartmann D and De Strooper B. Differential contribution of the three Aph1 genes to -secretase activity in vivo. Proc Natl Acad. Sci U.S.A. 2005 Feb 1; 102(5):1719-24. (Full pdf)

  • Cipolat S*, Rudka T*, Hartmann D*, Costa V, Serneels L, Craessaerts K, Metzger K, Frezza C, Annaert W, D'Adamio L, Derks C, Dejaegere T, Pellegrini L, D'Hooge R, Scorrano L and De Strooper B. Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodelling. Cell 2006 July 14; 126(1): 163-75. (Full pdf)

  • Martins IC*, Kuperstein I*, Wilkinson H, Maes E, Vanbrabant M, Jonckheere W, Van Gelder P, Hartmann D, D'Hooge R, De Strooper B, Schymkowitz J, Rousseau F. Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice. EMBO J. 2008 Jan 9; 27(1):224-33. (Full pdf) - * equal contribution

  • Hébert SS, Horré K, Nicolaï L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, Kauppinen S, Delacourte A, De Strooper B. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6415-20. (Full pdf)

  • Thathiah A, Spittaels K, Hoffmann M, Staes M, Cohen A, Horré K, Vanbrabant M, Coun F, Baekelandt V, Delacourte A, Fischer DF, Pollet D, De Strooper B, Merchiers P. The orphan g protein-coupled receptor 3 modulates amyloid-Beta Peptide generation in neurons. Science 2009 Feb 13;323(5916):946-51. (abstract) (pdf)

  • Serneels L*, Van Biervliet J*, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, Yang Z, May PC, Karran E, Wiltfang J, D'Hooge R, De Strooper B. Gamma-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease. Science 2009 May 1;324(5927):639-42 (abstract)(pdf) - * equal contribution

 

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