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Experimental Genetics Group - LEGTEGG






 
Bolleke Group Members Pijltje
  Head:
Stadhuis

Fred Van Leuven

Postdoctoral Researchers:
Natalia Crespo Biel

Predoctoral Researchers:
Anna Kremer, Hervé Maurin, Clara Theunis, Seon-Ah Chong

Technical Staff:
Peter Borghgraef, Herman Devijver, David Demedts, Benoît Lechat, Hugo Couto

Administration:
Gabriela Casteels


Visiting Scholars:
Clément Menuet (Marseille), Callum Parr (London),
Gosia Urbanska (IIMCB, Warszawa), Ilona Kondratiuk (Nencki, Warszawa),
Nadia Innamorato (Madrid), Limor Avrahami (Tel Aviv)
 
 
Bolleke Research Projects Pijltje
 
 White mouse

LEGTEGG is an academic research-group dedicated to understand fundamental mechanisms that underly normal processes of learning and memory, and become defective during ageing in Alzheimer's disease (AD).

LEGTEGG's main technical activities are the generation and in depth phenotyping of transgenic mice by behavioural, biochemical and pathological analysis.

 
Bolleke Transgenic Mouse Models Pijltje
     
 
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APP Transgenic Mice
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Tau Transgenic Mice
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APP x Tau Transgenic Mice
  APP  

Tau

 

  APP x Tau
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Click here for more information about these transgenic mice
 
     
Bolleke AAV models Pijltje
 

 

 
   
 
 
     
  BulletClick here for more information about these AAV models  
     
Bolleke Recent Publications Pijltje
 

dutschmann GSK-3α/β kinases and amyloid production in vivo.
JAWORSKI T, DEWACHTER I, LECHAT B, GEES M, KREMER A, DEMEDTS D, BORGHGRAEF P, DEVIJVER H, KÜGLER S, PATEL S, WOODGETT JR, VAN LEUVEN F.
Nature. 2011 Dec 8., (2010) 1802: 808-818
ABSTRACT - FULL TEXT

dutschmann Early Improved and Late Defective Cognition Is Reflected by Dendritic Spines in Tau.P301L Mice.
KREMER A, MAURIN H, DEMEDTS D, DEVIJVER H, BORGHGRAEF P, VAN LEUVEN F.
J Neurosci. 2011 Dec 7., 31(49):18036-47
ABSTRACT - FULL TEXT

dutschmann GSK3 and Alzheimer's Disease: Facts and Fiction ... .
KREMER A, LOUIS JV, JAWORSKI T, VAN LEUVEN F.
Front Mol Neurosci. 2011
, 4:17. Epub 2011 Aug 26
ABSTRACT - FULL TEXT

dutschmann Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study.
Chong SA, Benilova I, Shaban H, De Strooper B, Devijver H, Moechars D, Eberle W, Bartic C, Van Leuven F, Callewaert G.
Neurobiol Dis. 2011 Dec, 44(3):284-91. Epub 2011 Jul 18
ABSTRACT - FULL TEXT

dutschmann Dendritic Degeneration, Neurovascular Defects, and Inflammation Precede Neuronal Loss in a Mouse Model for Tau-Mediated Neurodegeneration.
Jaworski T, Lechat B, Demedts D, Gielis L, Devijver H, Borghgraef P, Duimel H, Verheyen F, Kügler S, Van Leuven F.
Am J Pathol. 2011 Oct., 179(4):2001-15. Epub 2011 Aug 10.
ABSTRACT - FULL TEXT


dutschmann Alzheimer's disease: Old problem, new views from transgenic and viral models.
JAWORSKI T, DEWACHTER I, SEYMOUR CM, BORGHGRAEF P, DEVIJVER H, KÜGLER S, VAN LEUVEN F.
Biochim Biophys Acta., (2010) 1802: 808-818

ABSTRACT - FULL TEXT

bolleke Upper airway dysfunction of Tau-P301L mice correlates with tauopathy in midbrain and ponto-medullary brainstem nuclei.
DUTSCHMANN M., MENUET C., STETTNER G.M., GESTREAU C., BORGHGRAEF P., DEVIJVER H., GIELIS L., HILAIRE G., VAN LEUVEN F.
J Neurosci., (2010) 30: 1810-1821

ABSTRACT - FULL TEXT
  
AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice.
JAWORSKI T, DEWACHTER I, LECHAT B, CROES S, TERMONT A, DEMEDTS D, BORGHGRAEF P, DEVIJVER H, FILIPKOWSKU RK, KACZMAREK L, KUGLER S, VAN LEUVEN F.
PLoS One., (2009) 4: e7280

ABSTRACT - FULL TEXT

 
Bolleke Artikels voor niet-experten
 
Het Syndroom Alzheimer
Dirk Draulans
Knack , 03 November 2010
VIEW ARTICLE

 
 
Onopgeloste plaques
Ir. Marga Van Zundert
C2W Life Sciences, (21) 10 November 2007
VIEW ARTICLE

 
  Een prik tegen Alzheimer
Kim De Rijck
De Standaard, 14 Juni 2007
VIEW ARTICLE


 
Bolleke Contact Pijltje
 
Experimental Genetics Group
Department of Human Genetics
Faculty of Medicine
K.U.Leuven
Campus Gasthuisberg - O&N1
Herestraat 49 bus 06.602
3000 LEUVEN
BELGIUM

Tel:  +32 16 33 07 14
Fax: +32 16 33 07 09
fred.vanleuven@med.kuleuven.be 
Laboratorium voor Experimentele Genetica en Transgenese
Departement Menselijke Erfelijkheid
Faculteit Geneeskunde
K.U.Leuven
Campus Gasthuisberg - O&N1
Herestraat 49 bus 602
3000 LEUVEN
BELGIE
 
 



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