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Experimental Genetics Group
Virchows Arch. 2002 May;440(5):485-90. Van Dorpe J1, Dal Cin P2, Weremowicz S2, Van Leuven F3, de Wever I4, Van den Berghe H3, Fletcher CD2, Sciot R5. 1Department of Pathology, AZ VUB Jette, Brussels, Belgium. 2Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA. 3Center for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium 4Surgical Oncology, University Hospitals, Katholieke Universiteit, Leuven, Leuven, Belgium. 5Deparmtent of Pathology, University Hospital St.-Raphaël, Katholieke Universiteit Leuven, Leuven, Belgium. Mesenchymomas are neoplasms in which there are at least two types of differentiated cells of mesenchymal derivation other than fibrous tissue. Chondrolipoangioma is a rare type of mesenchymoma composed predominantly of cartilage and adipose tissue with vascular elements and myxoid tissue present in lesser proportions. Cytogenetic analysis was performed on a case of chondrolipoangioma and revealed a t(12;15) (q13;q26) as the sole chromosome abnormality in 40 metaphases analyzed. However, using fluorescence in situ hybridization (FISH) analysis, a complex rearrangement was found involving chromosomes 2, 12, and 15, with a cryptic rearrangement of the gene ( HMGI-C; HMGA2) coding for high-mobility group I protein. This finding suggests a role for the HMGI-C gene also in the pathogenesis of this uncommon benign tumor type, in addition to its well-established role in the pathogenesis of common benign tumors such as lipomas, uterine leiomyomas, pulmonary chondroid hamartomas, and endometrial polyps.  FULL TEXT |
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