|
|
|
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
|
|
Experimental Genetics Group
Biochim Biophys Acta. 2008 Jul;1783(7):1381-95. Winderickx J1*, Delay C1,2, De Vos A1, Klinger H1, Pellens K1, Vanhelmont T1, Van Leuven F3, Zabrocki P1. 1Functional Biology, Katholieke Universiteit Leuven, Leuven-Heverlee, Belgium. 2Université Lille 2, Faculté de Médecine, Institut de Médecine Prédicive et de Recherche Thérapeutique, Lille, France. 3Experimental Genetics Group, Katholieke Universiteit Leuven, Leuven, Belgium. *Corresponding author. Budding yeast Saccharomyces cerevisiae has proven to be a valuable model organism for studying fundamental cellular processes across the eukaryotic kingdom including man. In this respect, complementation assays, in which the yeast protein is replaced by a homologous protein from another organism, have been very instructive. A newer trend is to use the yeast cell factory as a toolbox to understand cellular processes controlled by proteins for which the yeast lacks functional counterparts. An increasing number of studies have indicated that S. cerevisiae is a suitable model system to decipher molecular mechanisms involved in a variety of neurodegenerative disorders caused by aberrant protein folding. Here we review the current knowledge gained by the use of so-called humanized yeasts in the field of Huntington's, Parkinson's and Alzheimer's diseases.  FULL TEXT |
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 |
|
Copyright © Katholieke Universiteit Leuven | Comments on the content: Fred Van Leuven Production:Annick Vogels| Most recent update: October 21, 2009 | Disclaimer URL: http://med.kuleuven.be/legtegg/ |
